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GO Term :

Identifier  GO:0086095 Name  positive regulation of IKACh channel activity by G-protein coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate
Ontology . Name  GO Namespace  biological_process
Obsolete  false
description  A G-protein coupled acetylcholine receptor signaling pathway that contributes to a decrease in frequency or rate of heart contraction through activation of the IKACh potassium channel. Binding of acetylcholine to a G-protein coupled acetylcholine receptor (muscarinic receptor) on the surface of the signal-receiving cell results in liberation of the G-beta/gamma complex from the alpha subunit. The G-beta/gamma complex binds directly to the inward-rectifying potassium channel IKACh. Once the ion channel is activated, potassium ions (K+) flow out of the cell and cause it to hyperpolarize. In its hyperpolarized state, action potentials cannot be fired as quickly as possible, which slows the heart rate.
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Gene Ontology

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159 Parents

4 Synonyms

 

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1 Ontology

243 Relations