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Gene : CDH10 Homo sapiens

Name  ? cadherin 10 Cytological Location  5p14.2-p14.1
Brief Description  cadherin 10
description  This gene encodes a type II classical cadherin of the cadherin superfamily. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature cadherin protein. These integral membrane proteins mediate calcium-dependent cell-cell adhesion and are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. The extracellular domain consists of 5 subdomains, each containing a cadherin motif, and appears to determine the specificity of the protein's homophilic cell adhesion activity. Type II (atypical) cadherins are defined based on their lack of a histidine-alanine-valine (HAV) cell adhesion recognition sequence specific to type I cadherins. This particular cadherin is predominantly expressed in brain and is putatively involved in synaptic adhesions, axon outgrowth and guidance. Mutations in this gene may be associated with lung squamous cell carcinoma and colorectal cancer in human patients. [provided by RefSeq, Nov 2015]
  • synonyms:
  • cadherin 10, type 2 (T2-cadherin),
  • NM_006727,
  • AF039747,
  • OTTHUMG00000090667,
  • uc003jgr.3,
  • CDH10,
  • HGNC:1749
  • identifiers:
  • 1008,
  • ENSG00000040731,
  • CDH10

Genome feature

Region: gene ? Length: 157879  
Location: 5:24487100-24644978 reverse strand Cyto location: 5p14.2-p14.1


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559 SN Ps

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16 Data Sets

27 Homologues

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90 Rna Seq Results