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Gene : RASGRF1 Homo sapiens

Name  ? Ras protein specific guanine nucleotide releasing factor 1 Cytological Location  15q25.1
Brief Description  Ras protein specific guanine nucleotide releasing factor 1
description  The protein encoded by this gene is a guanine nucleotide exchange factor (GEF) similar to the Saccharomyces cerevisiae CDC25 gene product. Functional analysis has demonstrated that this protein stimulates the dissociation of GDP from RAS protein. The studies of the similar gene in mouse suggested that the Ras-GEF activity of this protein in brain can be activated by Ca2+ influx, muscarinic receptors, and G protein beta-gamma subunit. Mouse studies also indicated that the Ras-GEF signaling pathway mediated by this protein may be important for long-term memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Mar 2009]
  • synonyms:
  • M91815,
  • CDC25L,
  • CDC25,
  • GRF55,
  • PP13187,
  • GNRP,
  • OTTHUMG00000144172,
  • GRF1,
  • NM_002891,
  • CDC25,
  • ras-GRF1,
  • H-GRF55,
  • GRF55,
  • H-GRF55,
  • GRF1,
  • uc002bep.4,
  • CDC25L,
  • PP13187,
  • GNRP,
  • RASGRF1,
  • HGNC:9875
  • identifiers:
  • 5923,
  • ENSG00000058335,

Genome feature

Region: gene ? Length: 130927  
Location: 15:78959947-79090873 reverse strand Cyto location: 15q25.1

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138 SN Ps

5 Cross References

18 Data Sets

30 Homologues

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90 Rna Seq Results