help  | about  | cite  | software

Gene : CASP8 Homo sapiens

Name  ? caspase 8 Cytological Location  2q33.1
Brief Description  caspase 8
description  This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined. [provided by RefSeq, Jul 2008]
  • synonyms:
  • uc002uxt.2,
  • caspase 8, apoptosis-related cysteine protease,
  • FLICE,
  • MCH5,
  • ALPS2B,
  • caspase 8, apoptosis-related cysteine peptidase,
  • OTTHUMG00000132821,
  • MCH5,
  • NM_001228,
  • U60520,
  • MACH,
  • CAP4,
  • CASP8,
  • HGNC:1509,
  • MACH,
  • FLICE,
  • Casp-8,
  • Casp-8
  • identifiers:
  • 841,
  • ENSG00000064012,
  • CASP8

Genome feature

Region: gene ? Length: 54269  
Location: 2:201233443-201287711 Cyto location: 2q33.1


Uni Prot Comments Displayer

Protein Atlas Displayer

Gene Expression Atlas Tissues Displayer

Gene Expression Atlas Diseases Displayer

Publication Counts Displayer

Curated Proteins Displayer

Function

Gene Ontology Displayer

49 Pathways

Gene --> GO terms.

Mouse Gene --> Allele [Phenotype]

Genomics

J Browse Displayer

Gene Structure Displayer

Overlapping Features Displayer

Mouse Alleles Displayer

Gene --> Chromosomal location.

Gene --> GO terms.

Gene --> Overlapping genes.

Proteins

Gene --> Proteins.

SNPs

Gene Report --> GWAS hit

Disease

4 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Mouse Gene --> Allele [Phenotype]

Homology

Homologue Displayer

Gene --> Orthologues

Interactions

Cytoscape Network Displayer

Gene --> Physical and Genetic Interactions

Expression

Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.

 

Other

49 Pathways

2011 SN Ps

5 Cross References

20 Data Sets

20 Homologues

0 Located Features

90 Rna Seq Results