help  | about  | cite  | software

Gene : ERBB3 Homo sapiens

Name  ? erb-b2 receptor tyrosine kinase 3 Cytological Location  12q13.2
Brief Description  erb-b2 receptor tyrosine kinase 3
description  This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
  • synonyms:
  • LCCS2,
  • p45-sErbB3,
  • c-erbB-3,
  • erbB3-S,
  • p180-ErbB3,
  • HER3,
  • MDA-BF-1,
  • HGNC:3431,
  • HER3,
  • human epidermal growth factor receptor 3,
  • M34309,
  • uc001sjh.4,
  • OTTHUMG00000170140,
  • lethal congenital contracture syndrome 2,
  • ERBB3,
  • FERLK,
  • NM_001982,
  • v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3,
  • LCCS2,
  • ErbB-3,
  • c-erbB3,
  • p85-sErbB3
  • identifiers:
  • 2065,
  • ENSG00000065361,
  • ERBB3

Genome feature

Region: gene ? Length: 23483  
Location: 12:56080025-56103507 Cyto location: 12q13.2


Uni Prot Comments Displayer

Protein Atlas Displayer

Gene Expression Atlas Tissues Displayer

Gene Expression Atlas Diseases Displayer

Publication Counts Displayer

Curated Proteins Displayer

Function

Gene Ontology Displayer

Gene --> GO terms.

Mouse Gene --> Allele [Phenotype]

Genomics

J Browse Displayer

Gene Structure Displayer

Overlapping Features Displayer

Mouse Alleles Displayer

Gene --> Chromosomal location.

Gene --> GO terms.

Gene --> Overlapping genes.

Proteins

Gene --> Proteins.

SNPs

Gene Report --> GWAS hit

Disease

2 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Mouse Gene --> Allele [Phenotype]

Homology

Homologue Displayer

Gene --> Orthologues

Interactions

Cytoscape Network Displayer

Gene --> Physical and Genetic Interactions

Expression

Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.

 

Other

55 SN Ps

5 Cross References

20 Data Sets

59 Homologues

0 Located Features

90 Rna Seq Results