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Gene : SPEN Homo sapiens

Name  ? spen family transcriptional repressor Cytological Location  1p36.21-p36.13
Brief Description  spen family transcriptional repressor
description  This gene encodes a hormone inducible transcriptional repressor. Repression of transcription by this gene product can occur through interactions with other repressors, by the recruitment of proteins involved in histone deacetylation, or through sequestration of transcriptional activators. The product of this gene contains a carboxy-terminal domain that permits binding to other corepressor proteins. This domain also permits interaction with members of the NuRD complex, a nucleosome remodeling protein complex that contains deacetylase activity. In addition, this repressor contains several RNA recognition motifs that confer binding to a steroid receptor RNA coactivator; this binding can modulate the activity of both liganded and nonliganded steroid receptors. [provided by RefSeq, Jul 2008]
  • synonyms:
  • MINT,
  • NM_015001,
  • spen homolog, transcriptional regulator (Drosophila),
  • SPEN homolog, transcriptional regulator (Drosophila),
  • SPEN,
  • RBM15C,
  • OTTHUMG00000009376,
  • MINT,
  • SHARP,
  • HGNC:17575,
  • SHARP,
  • KIAA0929,
  • RBM15C,
  • uc001axk.2,
  • HIAA0929
  • identifiers:
  • 23013,
  • ENSG00000065526,
  • SPEN

Genome feature

Region: gene ? Length: 92592  
Location: 1:15847864-15940455 Cyto location: 1p36.21-p36.13

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0 Pathways

Gene --> GO terms.

Mouse Gene --> Allele [Phenotype]


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Gene --> Proteins.


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0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Mouse Gene --> Allele [Phenotype]


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Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.



0 Pathways

191 SN Ps

5 Cross References

17 Data Sets

11 Homologues

0 Located Features

90 Rna Seq Results