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Gene : MYLK Homo sapiens

Name  ? myosin light chain kinase Cytological Location  3q21.1
Brief Description  myosin light chain kinase
description  This gene, a muscle member of the immunoglobulin gene superfamily, encodes myosin light chain kinase which is a calcium/calmodulin dependent enzyme. This kinase phosphorylates myosin regulatory light chains to facilitate myosin interaction with actin filaments to produce contractile activity. This gene encodes both smooth muscle and nonmuscle isoforms. In addition, using a separate promoter in an intron in the 3' region, it encodes telokin, a small protein identical in sequence to the C-terminus of myosin light chain kinase, that is independently expressed in smooth muscle and functions to stabilize unphosphorylated myosin filaments. A pseudogene is located on the p arm of chromosome 3. Four transcript variants that produce four isoforms of the calcium/calmodulin dependent enzyme have been identified as well as two transcripts that produce two isoforms of telokin. Additional variants have been identified but lack full length transcripts. [provided by RefSeq, Jul 2008]
  • synonyms:
  • smMLCK,
  • MLCK210,
  • NM_053025,
  • X85337,
  • myosin, light polypeptide kinase,
  • MLCK1,
  • MLCK,
  • MSTP083,
  • MLCK1,
  • MLCK,
  • smooth muscle myosin light chain kinase,
  • MYLK1,
  • MLCK108,
  • smMLCK,
  • OTTHUMG00000141304,
  • HGNC:7590,
  • uc062ncr.1,
  • KRP,
  • MYLK1,
  • MYLK,
  • AAT7
  • identifiers:
  • 4638,
  • ENSG00000065534,
  • MYLK

Genome feature

Region: gene ? Length: 272007  
Location: 3:123612296-123884302 reverse strand Cyto location: 3q21.1


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1 Diseases

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47 SN Ps

5 Cross References

20 Data Sets

4 Homologues

0 Located Features

90 Rna Seq Results