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Gene : TIE1 Homo sapiens

Name  ? tyrosine kinase with immunoglobulin like and EGF like domains 1 Cytological Location  1p34.2
Brief Description  tyrosine kinase with immunoglobulin like and EGF like domains 1
description  This gene encodes a member of the tyrosine protein kinase family. The encoded protein plays a critical role in angiogenesis and blood vessel stability by inhibiting angiopoietin 1 signaling through the endothelial receptor tyrosine kinase Tie2. Ectodomain cleavage of the encoded protein relieves inhibition of Tie2 and is mediated by multiple factors including vascular endothelial growth factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
  • synonyms:
  • JTK14,
  • OTTHUMG00000007282,
  • TIE1,
  • TIE,
  • TIE,
  • uc001ciu.4,
  • tyrosine kinase with immunoglobulin and epidermal growth factor homology domains 1,
  • BC038239,
  • JTK14,
  • NM_005424,
  • HGNC:11809,
  • tyrosine kinase with immunoglobulin-like and EGF-like domains 1
  • identifiers:
  • 7075,
  • ENSG00000066056,
  • TIE1

Genome feature

Region: gene ? Length: 22216  
Location: 1:43300895-43323110 Cyto location: 1p34.2

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0 Pathways

Gene --> GO terms.

Mouse Gene --> Allele [Phenotype]


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0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Mouse Gene --> Allele [Phenotype]


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Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.



0 Pathways

2011 SN Ps

5 Cross References

15 Data Sets

56 Homologues

0 Located Features

90 Rna Seq Results