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Pathway : B cell receptor signaling pathway

Identifier  04662 Description  B cells are an important component of adaptive immunity They produce and secrete millions of different antibody molecules, each of which recognizes a different foreign antigen The B cell receptor BCR is an integral membrane protein complex that is composed of two immunoglobulin Ig heavy chains, two Ig light chains and two heterodimers of Ig-alpha and Ig-beta After BCR ligation by antigen, three main protein tyrosine kinases PTKs -the SRC-family kinase LYN, SYK and the TEC-family kinase BTK- are activated Phosphatidylinositol 3-kinase PI3K and phospholipase C-gamma 2 PLC-gamma 2 are important downstream effectors of BCR signalling This signalling ultimately results in the expression of immediate early genes that further activate the expression of other genes involved in B cell proliferation, differentiation and Ig production as well as other processes

1 Data Sets

151 Genes

0 Proteins