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Pathway : RIG-I-like receptor signaling pathway

Identifier  04622 Description  Specific families of pattern recognition receptors are responsible for detecting viral pathogens and generating innate immune responses Non-self RNA appearing in a cell as a result of intracellular viral replication is recognized by a family of cytosolic RNA helicases termed RIG-I-like receptors RLRs The RLR proteins include RIG-I, MDA5, and LGP2 and are expressed in both immune and nonimmune cells Upon recognition of viral nucleic acids, RLRs recruit specific intracellular adaptor proteins to initiate signaling pathways that lead to the synthesis of type I interferon and other inflammatory cytokines, which are important for eliminating viruses

1 Data Sets

140 Genes

0 Proteins