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Pathway : Leukocyte transendothelial migration

Identifier  04670 Description  Leukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules CAM and then migrate across the vascular endothelium A leukocyte adherent to CAMs on the endothelial cells moves forward by leading-edge protrusion and retraction of its tail In this process, alphaL /beta2 integrin activates through Vav1, RhoA, which subsequently activates the kinase p160ROCK ROCK activation leads to MLC phosphorylation, resulting in retraction of the actin cytoskeleton Moreover, Leukocytes activate endothelial cell signals that stimulate endothelial cell retraction during localized dissociation of the endothelial cell junctions ICAM-1-mediated signals activate an endothelial cell calcium flux and PKC, which are required for ICAM-1 dependent leukocyte migration VCAM-1 is involved in the opening of the "endothelial passage" through which leukocytes can extravasate In this regard, VCAM-1 ligation induces NADPH oxidase activation and the production of reactive oxygen species ROS in a Rac-mediated manner, with subsequent activation of matrix metallopoteinases and loss of VE-cadherin-mediated adhesion

1 Data Sets

236 Genes

0 Proteins