help  | about  | cite  | software

Pathway : ABC transporters

Identifier  02010 Description  The ATP-binding cassette ABC transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes They couple ATP hydrolysis to active transport of a wide variety of substrates such as ions, sugars, lipids, sterols, peptides, proteins, and drugs The structure of a prokaryotic ABC transporter usually consists of three components; typically two integral membrane proteins each having six transmembrane segments, two peripheral proteins that bind and hydrolyze ATP, and a periplasmic or lipoprotein substrate-binding protein Many of the genes for the three components form operons as in fact observed in many bacterial and archaeal genomes On the other hand, in a typical eukaryotic ABC transporter, the membrane spanning protein and the ATP-binding protein are fused, forming a multi-domain protein with the membrane-spanning domain MSD and the nucleotide-binding domain NBD

1 Data Sets

89 Genes

0 Proteins