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Pathway : Endocrine and other factor-regulated calcium reabsorption

Identifier  04961 Description  Calcium Ca2 is essential for numerous physiological functions including intracellular signalling processes, neuronal excitability, muscle contraction and bone formation Therefore, its homeostasis is finely maintained through the coordination of intestinal absorption, renal reabsorption, and bone resorption In kidney, the late part of the distal convoluted tubule DCT and the connecting tubule CNT are the site of active Ca2 transport and precisely regulate Ca2 reabsorption Following Ca2 entry through TRPV5, Ca2 bound to calbindin-D28K diffuses to the basolateral side, where it is extruded into the blood compartment through NCX1 and to a lesser extent PMCA1b In the urinary compartment, both klotho and tissue kallikrein TK increase the apical abundance of TRPV5 In the blood compartment, PTH, 1,25OH2D3 and estrogen increase the transcription and protein expression of  the luminal Ca2 channels, calbindins, and the extrusion systems

1 Data Sets

105 Genes

0 Proteins