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Pathway : Protein processing in endoplasmic reticulum

Identifier  04141 Description  The endoplasmic reticulum ER is a subcellular organelle where proteins are folded with the help of lumenal chaperones Newly synthesized peptides enter the ER via the sec61 pore and are glycosylated Correctly folded proteins are packaged into transport vesicles that shuttle them to the Golgi complex Misfolded proteins are retained within the ER lumen in complex with molecular chaperones Proteins that are terminally misfolded bind to BiP and are directed toward degradation through the proteasome in a process called ER-associated degradation ERAD Accumulation of misfolded proteins in the ER causes ER stress and activates a signaling pathway called the unfolded protein response UPR In certain severe situations, however, the protective mechanisms activated by the UPR are not sufficient to restore normal ER function and cells die by apoptosis

1 Data Sets

333 Genes

0 Proteins