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Pathway : Huntington's disease

Identifier  05016 Description  Huntington disease HD is an autosomal-dominant neurodegenerative disorder that primarily affects medium spiny striatal neurons MSN The symptoms are choreiform, involuntary movements, personality changes and dementia HD is caused by a CAG repeat expansion in the IT15gene, which results in a long stretch of polyglutamine close to the amino-terminus of the HD protein huntingtin Htt Mutant Htt mHtt has effects both in the cytoplasm and in the nucleus In the cytoplasm, full-length mHtt can interfere with BDNF vesicular transport on microtubules This mutant protein also may lead to abnormal endocytosis and secretion in neurons, because normal Htt form a complex with the proteins Hip1, clathrin and AP2 that are involved in endocytosis In addition, mHtt affects Ca2 signaling by sensitizing InsP3R1 to activation by InsP3, stimulating NMDAR activity, and destabilizing mitochondrial Ca2 handling The mHtt translocates to the nucleus, where it forms intranuclear inclusions Nuclear toxicity is believed to be caused by interference with gene transcription, leading to loss of transcription of neuroprotective molecules such as BDNF While mHtt binds to p53 and upregulates levels of nuclear p53 as well as p53 transcriptional activity Augmented p53 mediates mitochondrial dysfunction

1 Data Sets

374 Genes

0 Proteins