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Pathway : RNA degradation

Identifier  03018 Description  The correct processing, quality control and turnover of cellular RNA molecules are critical to many aspects in the expression of genetic information In eukaryotes, two major pathways of mRNA decay exist and both pathways are initiated by polyA shortening of the mRNA In the 5' to 3' pathway, this is followed by decapping which then permits the 5' to 3' exonucleolytic degradation of transcripts In the 3' to 5' pathway, the exosome, a large multisubunit complex, plays a key role The exosome exists in archaeal cells, too In bacteria, endoribonuclease E, a key enzyme involved in RNA decay and processing, organizes a protein complex called degradosome RNase E or R interacts with the phosphate-dependent exoribonuclease polynucleotide phosphorylase, DEAD-box helicases, and additional factors in the RNA-degrading complex

1 Data Sets

145 Genes

0 Proteins