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Pathway : Type I diabetes mellitus

Identifier  04940 Description  Type I diabetes mellitus is a disease that results from autoimmune destruction of the insulin-producing beta-cells Certain beta-cell proteins act as autoantigens after being processed by antigen-presenting cell APC, such as macrophages and dendritic cells, and presented in a complex with MHC-II molecules on the surface of the APC Then immunogenic signals from APC activate CD4 T cells, predominantly of the Th1 subset Antigen-activated Th1 cells produce IL-2 and IFNgamma They activate macrophages and cytotoxic CD8 T cells, and these effector cells may kill islet beta-cells by one or both of two types of mechanisms: 1 direct interactions of antigen-specific cytotoxic T cells with a beta-cell autoantigen-MHC-I complex on the beta-cell, and 2 non-specific inflammatory mediators, such as free radicals/oxidants and cytokines IL-1, TNFalpha, TNFbeta, IFNgamma

1 Data Sets

101 Genes

0 Proteins