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Pathway : Viral myocarditis

Identifier  05416 Description  Myocarditis is a cardiac disease associated with inflammation and injury of the myocardium It results from various etiologies, both noninfectious and infectious, but coxsackievirus B3 CVB3 is still considered the dominant etiological agent Myocarditis may be caused by direct cytopathic effects of virus, a pathologic immune response to persistent virus, or autoimmunity triggered by the viral infection The virus enters the myocyte through internalization of the coxsackie-adenoviral receptor CAR and its coreceptor, decay-accelerating factor DAF Viral proteases cleave various proteins in the host cell One example is viral protease 2A, which cleaves eukaryote initiation factor 4G eIF4G and the dystrophin protein, resulting in a complete shutdown of cap-dependent RNA translation and cytoskeletal destruction in infected cardiomyocytes, respectively CVB3 also cleaves the member of the Bcl-2 family Bid, leading to apoptosis CVB3 infection also induces the cleavage of cyclin D protein through a proteasome-dependent pathway, leading to the host cell-growth arrest Viral infection and necrosis of myocytes may lead to the release of intracellular antigens, resulting in activation of self-reactive T cells CVB infection is a significant cause of dilated cardiomyopathy DCM as well as myocarditis Epidemiologically, myocarditis underlies a significant portion of patients with DCM

1 Data Sets

158 Genes

0 Proteins