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Pathway : MAPK signaling pathway

Identifier  04010 Description  The mitogen-activated protein kinase MAPK cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases ERK-1/2, Jun amino-terminal kinases JNK1/2/3, p38 proteins p38alpha/beta/gamma/delta and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 JNKK1/2 for the JNKs, and MEK5 for ERK5 Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling Presumably each MAPKKK confers responsiveness to distinct stimuli For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli

1 Data Sets

535 Genes

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