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Pathway : T cell receptor signaling pathway

Identifier  04660 Description  Activation of T lymphocytes is a key event for an efficient response of the immune system It requires the involvement of the T-cell receptor TCR as well as costimulatory molecules such as CD28 Engagement of these receptors through the interaction with a foreign antigen associated with major histocompatibility complex molecules and CD28 counter-receptors B71/B72, respectively, results in a series of signaling cascades These cascades comprise an array of protein-tyrosine kinases, phosphatases, GTP-binding proteins and adaptor proteins that regulate generic and specialised functions, leading to T-cell proliferation, cytokine production and differentiation into effector cells

1 Data Sets

217 Genes

0 Proteins