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Pathway : Pancreatic secretion

Identifier  04972 Description  The pancreas performs both exocrine and endocrine functions  The exocrine pancreas consists of two parts, the acinar and duct cells The primary functions of pancreatic acinar cells are to synthesize and secrete digestive enzymes Stimulation of the cell by secretagogues such as acetylcholine ACh and cholecystokinin CCK causes the generation of an intracellular Ca2 signal This signal, in turn, triggers the fusion of the zymogen granules with the apical plasma membrane, leading to the polarised secretion of the enzymes The major task of pancreatic duct cells is the secretion of fluid and bicarbonate ions HCO3-, which neutralize the acidity of gastric contents that enter the duodenum An increase in intracellular cAMP by secretin is one of the major signals of pancreatic HCO3- secretion Activation of the CFTR Cl- channel and the CFTR-dependent Cl-/HCO3- exchange activities is responsible for cAMP-induced HCO3- secretion

1 Data Sets

205 Genes

0 Proteins