help  | about  | cite  | software

Gene : TNK2 Homo sapiens

Name  ? tyrosine kinase non receptor 2 Cytological Location  3q29
Brief Description  tyrosine kinase non receptor 2
description  This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq, Jul 2008]
  • synonyms:
  • ACK1,
  • OTTHUMG00000155737,
  • uc003fvu.2,
  • L13738,
  • ACK1,
  • HGNC:19297,
  • ACK,
  • tyrosine kinase, non-receptor, 2,
  • ACK,
  • activated Cdc42-associated kinase 1,
  • TNK2,
  • NM_005781,
  • ACK-1,
  • p21cdc42Hs,
  • p21cdc42Hs
  • identifiers:
  • 10188,
  • ENSG00000061938,
  • TNK2

Genome feature

Region: gene ? Length: 45646  
Location: 3:195863364-195909009 reverse strand Cyto location: 3q29


Uni Prot Comments Displayer

Protein Atlas Displayer

Gene Expression Atlas Tissues Displayer

Gene Expression Atlas Diseases Displayer

Publication Counts Displayer

Curated Proteins Displayer

Function

Gene Ontology Displayer

0 Pathways

Gene --> GO terms.

Mouse Gene --> Allele [Phenotype]

Genomics

J Browse Displayer

Gene Structure Displayer

Overlapping Features Displayer

Mouse Alleles Displayer

Gene --> Chromosomal location.

Gene --> GO terms.

Gene --> Overlapping genes.

Proteins

Gene --> Proteins.

SNPs

Gene Report --> GWAS hit

Disease

0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Mouse Gene --> Allele [Phenotype]

Homology

Homologue Displayer

Gene --> Orthologues

Interactions

Cytoscape Network Displayer

Gene --> Physical and Genetic Interactions

Expression

Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.

 

Other

0 Pathways

306 SN Ps

5 Cross References

17 Data Sets

36 Homologues

0 Located Features

90 Rna Seq Results