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Gene : MAP2K4 Homo sapiens

Name  ? mitogen-activated protein kinase kinase 4 Cytological Location  17p12
Brief Description  mitogen-activated protein kinase kinase 4
description  This gene encodes a member of the mitogen-activated protein kinase (MAPK) family. Members of this family act as an integration point for multiple biochemical signals and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. They form a three-tiered signaling module composed of MAPKKKs, MAPKKs, and MAPKs. This protein is phosphorylated at serine and threonine residues by MAPKKKs and subsequently phosphorylates downstream MAPK targets at threonine and tyrosine residues. A similar protein in mouse has been reported to play a role in liver organogenesis. A pseudogene of this gene is located on the long arm of chromosome X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
  • synonyms:
  • SAPKK1,
  • SERK1,
  • PRKMK4,
  • OTTHUMG00000178267,
  • JNKK,
  • SEK1,
  • L36870,
  • MAPKK4,
  • MEK4,
  • MKK4,
  • NM_001281435,
  • SERK1,
  • MKK4,
  • SAPKK-1,
  • MAP2K4,
  • SKK1,
  • uc002gnj.5,
  • PRKMK4,
  • MEK4,
  • HGNC:6844,
  • JNKK1,
  • JNKK1
  • identifiers:
  • 6416,
  • ENSG00000065559,
  • MAP2K4

Genome feature

Region: gene ? Length: 123014  
Location: 17:12020818-12143831 Cyto location: 17p12

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43 Pathways

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene --> Chromosomal location.

Gene --> GO terms.

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Gene --> Proteins.


Gene Report --> GWAS hit


0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene --> Orthologues


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Gene --> Physical and Genetic Interactions


Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.



43 Pathways

587 SN Ps

5 Cross References

17 Data Sets

53 Homologues

0 Located Features

90 Rna Seq Results