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Gene : CTTN Homo sapiens

Name  ? cortactin Cytological Location  11q13.3
Brief Description  cortactin
description  This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene. [provided by RefSeq, May 2010]
  • synonyms:
  • AJ288897,
  • EMS1,
  • uc001opw.5,
  • ems1 sequence (mammary tumor and squamous cell carcinoma-associated (p80/85 src substrate),
  • EMS1,
  • HGNC:3338,
  • NM_138565,
  • OTTHUMG00000134307,
  • CTTN
  • identifiers:
  • 2017,
  • ENSG00000085733,
  • CTTN

Genome feature

Region: gene ? Length: 38079  
Location: 11:70398506-70436584 Cyto location: 11q13.3


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Proteins

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SNPs

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Disease

0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

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Homology

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Expression

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2011 SN Ps

5 Cross References

16 Data Sets

9 Homologues

0 Located Features

90 Rna Seq Results