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Gene : CDK6 Homo sapiens

Name  ? cyclin dependent kinase 6 Cytological Location  7q21.2
Brief Description  cyclin dependent kinase 6
description  The protein encoded by this gene is a member of the CMGC family of serine/threonine protein kinases. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. Altered expression of this gene has been observed in multiple human cancers. A mutation in this gene resulting in reduced cell proliferation, and impaired cell motility and polarity, and has been identified in patients with primary microcephaly. [provided by RefSeq, Aug 2017]
  • synonyms:
  • PLSTIRE,
  • PLSTIRE,
  • OTTHUMG00000131697,
  • HGNC:1777,
  • CDK6,
  • uc011khw.2,
  • MCPH12,
  • NM_001145306
  • identifiers:
  • 1021,
  • ENSG00000105810,
  • CDK6

Genome feature

Region: gene ? Length: 231707  
Location: 7:92604921-92836627 reverse strand Cyto location: 7q21.2


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Gene -> HPO annotation (Human Phenotype Ontology)

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Genomics

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Proteins

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SNPs

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Disease

1 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Homology

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Expression

Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

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Other

43 SN Ps

5 Cross References

20 Data Sets

34 Homologues

0 Located Features

90 Rna Seq Results