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Gene : MET Homo sapiens

Name  ? MET proto-oncogene, receptor tyrosine kinase Cytological Location  7q31.2
Brief Description  MET proto-oncogene, receptor tyrosine kinase
description  This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide, which has been shown to reduce lung fibrosis. Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, which plays a role in cellular survival, embryogenesis, and cellular migration and invasion. Mutations in this gene are associated with papillary renal cell carcinoma, hepatocellular carcinoma, and various head and neck cancers. Amplification and overexpression of this gene are also associated with multiple human cancers. [provided by RefSeq, May 2016]
  • synonyms:
  • DFNB97,
  • DFNB97,
  • RCCP2,
  • M35073,
  • MET,
  • uc003vij.4,
  • met proto-oncogene,
  • HGFR,
  • OTTHUMG00000023299,
  • NM_000245,
  • hepatocyte growth factor receptor,
  • HGFR,
  • RCCP2,
  • c-Met,
  • HGNC:7029,
  • AUTS9
  • identifiers:
  • 4233,
  • ENSG00000105976,
  • MET

Genome feature

Region: gene ? Length: 126028  
Location: 7:116672359-116798386 Cyto location: 7q31.2


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Function

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49 Pathways

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Genomics

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Gene --> Chromosomal location.

Gene --> GO terms.

Gene --> Overlapping genes.

Proteins

Gene --> Proteins.

SNPs

Gene Report --> GWAS hit

Disease

4 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Homology

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Interactions

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Gene --> Physical and Genetic Interactions

Expression

Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.

 

Other

49 Pathways

2011 SN Ps

5 Cross References

20 Data Sets

58 Homologues

2 Located Features

90 Rna Seq Results