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Gene : WASF1 Homo sapiens

Name  ? WASP family member 1 Cytological Location  6q21
Brief Description  WAS protein family member 1
description  The protein encoded by this gene, a member of the Wiskott-Aldrich syndrome protein (WASP)-family, plays a critical role downstream of Rac, a Rho-family small GTPase, in regulating the actin cytoskeleton required for membrane ruffling. It has been shown to associate with an actin nucleation core Arp2/3 complex while enhancing actin polymerization in vitro. Wiskott-Aldrich syndrome is a disease of the immune system, likely due to defects in regulation of actin cytoskeleton. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
  • synonyms:
  • SCAR1,
  • SCAR1,
  • WAS protein family member 1,
  • WAVE1,
  • WASF1,
  • WAVE1,
  • WAS protein family, member 1,
  • uc003ptv.1,
  • HGNC:12732,
  • D87459,
  • NM_003931,
  • KIAA0269,
  • WAVE,
  • WAVE,
  • OTTHUMG00000015357
  • identifiers:
  • 8936,
  • ENSG00000112290,
  • WASF1

Genome feature

Region: gene ? Length: 80186  
Location: 6:110099819-110180004 reverse strand Cyto location: 6q21


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Disease

0 Diseases

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2011 SN Ps

5 Cross References

17 Data Sets

8 Homologues

2 Located Features

90 Rna Seq Results