help  | about  | cite  | software

Gene : IL4 Homo sapiens

Name  ? interleukin 4 Cytological Location  5q31.1
Brief Description  interleukin 4
description  The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. This gene, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
  • synonyms:
  • BSF-1,
  • BCGF1,
  • IL4,
  • B_cell stimulatory factor 1,
  • NM_000589,
  • M23442,
  • BSF1,
  • OTTHUMG00000059724,
  • MGC79402,
  • uc003kxk.3,
  • BCGF-1,
  • lymphocyte stimulatory factor 1,
  • HGNC:6014,
  • BCGF-1,
  • BCGF1,
  • B cell growth factor 1,
  • IL-4,
  • IL-4,
  • BSF1
  • identifiers:
  • 3565,
  • ENSG00000113520,
  • IL4

Genome feature

Region: gene ? Length: 8693  
Location: 5:132673986-132682678 Cyto location: 5q31.1


Uni Prot Comments Displayer

Protein Atlas Displayer

Gene Expression Atlas Tissues Displayer

Gene Expression Atlas Diseases Displayer

Publication Counts Displayer

Curated Proteins Displayer

Function

Gene Ontology Displayer

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Genomics

J Browse Displayer

Gene Structure Displayer

Overlapping Features Displayer

Mouse Alleles Displayer

Gene --> Chromosomal location.

Gene --> GO terms.

Gene --> Overlapping genes.

Proteins

Gene --> Proteins.

SNPs

Gene Report --> GWAS hit

Disease

0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Homology

Homologue Displayer

Gene --> Orthologues

Interactions

Cytoscape Network Displayer

Gene --> Physical and Genetic Interactions

Expression

Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.

 

Other

236 SN Ps

5 Cross References

16 Data Sets

2 Homologues

0 Located Features

90 Rna Seq Results