help  | about  | cite  | software

Gene : CD86 Homo sapiens

Name  ? CD86 molecule Cytological Location  3q13.33
Brief Description  CD86 molecule
description  This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in several transcript variants encoding different isoforms.[provided by RefSeq, May 2011]
  • synonyms:
  • CD28LG2,
  • B7.2,
  • B7-2,
  • CD86,
  • B7-2,
  • uc003eet.4,
  • LAB72,
  • CD28LG2,
  • B70,
  • OTTHUMG00000159482,
  • B7.2,
  • HGNC:1705,
  • B-lymphocyte antigen B7-2,
  • CD86 antigen (CD28 antigen ligand 2, B7-2 antigen),
  • NM_006889
  • identifiers:
  • 942,
  • ENSG00000114013,
  • CD86

Genome feature

Region: gene ? Length: 65782  
Location: 3:122055362-122121143 Cyto location: 3q13.33


Uni Prot Comments Displayer

Protein Atlas Displayer

Gene Expression Atlas Tissues Displayer

Gene Expression Atlas Diseases Displayer

Publication Counts Displayer

Curated Proteins Displayer

Function

Gene Ontology Displayer

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Genomics

J Browse Displayer

Gene Structure Displayer

Overlapping Features Displayer

Mouse Alleles Displayer

Gene --> Chromosomal location.

Gene --> GO terms.

Gene --> Overlapping genes.

Proteins

Gene --> Proteins.

SNPs

Gene Report --> GWAS hit

Disease

0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Homology

Homologue Displayer

Gene --> Orthologues

Interactions

Cytoscape Network Displayer

Gene --> Physical and Genetic Interactions

Expression

Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.

 

Other

20 SN Ps

5 Cross References

17 Data Sets

6 Homologues

0 Located Features

90 Rna Seq Results