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Gene : VPS4B Homo sapiens

Name  ? vacuolar protein sorting 4 homolog B Cytological Location  18q21.33
Brief Description  vacuolar protein sorting 4 homolog B
description  The protein encoded by this gene is a member of the AAA protein family (ATPases associated with diverse cellular activities), and is the homolog of the yeast Vps4 protein. In humans, two paralogs of the yeast protein have been identified. The former share a high degree of aa sequence similarity with each other, and also with yeast Vps4 and mouse Skd1 proteins. Mouse Skd1 (suppressor of K+ transport defect 1) has been shown to be a yeast Vps4 ortholog. Functional studies indicate that both human paralogs associate with the endosomal compartments, and are involved in intracellular protein trafficking, similar to Vps4 protein in yeast. The gene encoding this paralog has been mapped to chromosome 18; the gene for the other resides on chromosome 16. [provided by RefSeq, Jul 2008]
  • synonyms:
  • SKD1,
  • uc002lix.4,
  • suppressor of K+ transport defect 1,
  • AF038960,
  • VPS4-2,
  • SKD1B,
  • VPS4-2,
  • VPS4B,
  • MIG1,
  • vacuolar protein sorting 4 homolog B (S. cerevisiae),
  • SKD1B,
  • OTTHUMG00000132790,
  • NM_004869,
  • HGNC:10895,
  • SKD1,
  • vacuolar protein sorting 4B (yeast)
  • identifiers:
  • 9525,
  • ENSG00000119541,
  • VPS4B

Genome feature

Region: gene ? Length: 33330  
Location: 18:63389190-63422519 reverse strand Cyto location: 18q21.33

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0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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42 SN Ps

5 Cross References

16 Data Sets

12 Homologues

0 Located Features

90 Rna Seq Results