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Gene : FLT3 Homo sapiens

Name  ? fms related tyrosine kinase 3 Cytological Location  13q12.2
Brief Description  fms related tyrosine kinase 3
description  This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. [provided by RefSeq, Jan 2015]
  • synonyms:
  • NM_004119,
  • HGNC:3765,
  • U02687,
  • OTTHUMG00000016646,
  • FLK2,
  • CD135,
  • FLK2,
  • fms-related tyrosine kinase 3,
  • FLT3,
  • FLK-2,
  • uc001urw.3,
  • CD135,
  • STK1,
  • STK1
  • identifiers:
  • 2322,
  • ENSG00000122025,
  • FLT3

Genome feature

Region: gene ? Length: 97319  
Location: 13:28003274-28100592 reverse strand Cyto location: 13q12.2


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Proteins

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SNPs

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Disease

2 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

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Gene -> HPO annotation (Human Phenotype Ontology)

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Homology

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Expression

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Other

2011 SN Ps

5 Cross References

19 Data Sets

72 Homologues

0 Located Features

90 Rna Seq Results