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Gene : PKN1 Homo sapiens

Name  ? protein kinase N1 Cytological Location  19p13.12
Brief Description  protein kinase N1
description  The protein encoded by this gene belongs to the protein kinase C superfamily. This kinase is activated by Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can be activated by phospholipids and by limited proteolysis. The 3-phosphoinositide dependent protein kinase-1 (PDPK1/PDK1) is reported to phosphorylate this kinase, which may mediate insulin signals to the actin cytoskeleton. The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
  • synonyms:
  • S75546,
  • protein kinase C-like 1,
  • uc002myp.4,
  • NM_213560,
  • PRK1,
  • OTTHUMG00000039611,
  • PKN,
  • NM_002741,
  • DBK,
  • PRKCL1,
  • PKN,
  • PAK-1,
  • MGC46204,
  • HGNC:9405,
  • PAK1,
  • PRK1,
  • PKN-ALPHA,
  • DBK,
  • PAK1,
  • PKN1,
  • PRKCL1
  • identifiers:
  • 5585,
  • ENSG00000123143,
  • PKN1

Genome feature

Region: gene ? Length: 38514  
Location: 19:14433354-14471867 Cyto location: 19p13.12


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Disease

0 Diseases

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Expression

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Other

63 SN Ps

5 Cross References

15 Data Sets

40 Homologues

0 Located Features

90 Rna Seq Results