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Gene : RFX1 Homo sapiens

Name  ? regulatory factor X1 Cytological Location  19p13.12
Brief Description  regulatory factor X1
description  This gene encodes a member of the regulatory factor X (RFX) family of transcription factors, which are characterized by a winged-helix DNA-binding domain. The encoded transcription factor contains an N-terminal activation domain and a C-terminal repression domain, and may activate or repress target gene expression depending on cellular context. This transcription factor has been shown to regulate a wide variety of genes involved in immunity and cancer, including the MHC class II genes and genes that may be involved in cancer progression. This gene exhibits altered expression in glioblastoma and the autoimmune disease systemic lupus erythematosis (SLE). [provided by RefSeq, Jul 2016]
  • synonyms:
  • RFX,
  • HGNC:9982,
  • NM_002918,
  • EFC,
  • regulatory factor X, 1 (influences HLA class II expression),
  • uc002mxv.4,
  • enhancer factor C,
  • OTTHUMG00000181979,
  • RFX1,
  • MHC class II regulatory factor RFX,
  • EF-C,
  • trans-acting regulatory factor 1
  • identifiers:
  • 5989,
  • ENSG00000132005,
  • RFX1

Genome feature

Region: gene ? Length: 45985  
Location: 19:13961530-14007514 reverse strand Cyto location: 19p13.12

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0 Pathways

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene --> Chromosomal location.

Gene --> GO terms.

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Gene --> Proteins.


Gene Report --> GWAS hit


0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene --> Orthologues


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Gene --> Physical and Genetic Interactions


Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.



0 Pathways

22 SN Ps

5 Cross References

16 Data Sets

13 Homologues

0 Located Features

90 Rna Seq Results