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Gene : EIF2S1 Homo sapiens

Name  ? eukaryotic translation initiation factor 2 subunit alpha Cytological Location  14q23.3
Brief Description  eukaryotic translation initiation factor 2 subunit alpha
description  The translation initiation factor EIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, EIF2, and GTP. EIF2 is composed of 3 nonidentical subunits, the 36-kD EIF2-alpha subunit (EIF2S1), the 38-kD EIF2-beta subunit (EIF2S2; MIM 603908), and the 52-kD EIF2-gamma subunit (EIF2S3; MIM 300161). The rate of formation of the ternary complex is modulated by the phosphorylation state of EIF2-alpha (Ernst et al., 1987 [PubMed 2948954]).[supplied by OMIM, Feb 2010]
  • synonyms:
  • NM_004094,
  • uc001xjg.4,
  • EIF-2alpha,
  • eukaryotic translation initiation factor 2, subunit 1 (alpha, 35kD ),
  • EIF2S1,
  • OTTHUMG00000029800,
  • eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa,
  • EIF-2alpha,
  • EIF2A,
  • EIF2,
  • EIF-2A,
  • EIF2,
  • EIF-2,
  • J02645,
  • EIF2A,
  • HGNC:3265
  • identifiers:
  • 1965,
  • ENSG00000134001,
  • EIF2S1

Genome feature

Region: gene ? Length: 26200  
Location: 14:67360317-67386516 Cyto location: 14q23.3

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2011 SN Ps

5 Cross References

16 Data Sets

7 Homologues

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90 Rna Seq Results