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Gene : ALDOB Homo sapiens

Name  ? aldolase, fructose-bisphosphate B Cytological Location  9q31.1
Brief Description  aldolase, fructose-bisphosphate B
description  Fructose-1,6-bisphosphate aldolase (EC 4.1.2.13) is a tetrameric glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Vertebrates have 3 aldolase isozymes which are distinguished by their electrophoretic and catalytic properties. Differences indicate that aldolases A, B, and C are distinct proteins, the products of a family of related 'housekeeping' genes exhibiting developmentally regulated expression of the different isozymes. The developing embryo produces aldolase A, which is produced in even greater amounts in adult muscle where it can be as much as 5% of total cellular protein. In adult liver, kidney and intestine, aldolase A expression is repressed and aldolase B is produced. In brain and other nervous tissue, aldolase A and C are expressed about equally. There is a high degree of homology between aldolase A and C. Defects in ALDOB cause hereditary fructose intolerance. [provided by RefSeq, Dec 2008]
  • synonyms:
  • HGNC:417,
  • aldolase B, fructose-bisphosphate,
  • NM_000035,
  • ALDB,
  • ALDOB,
  • OTTHUMG00000020378,
  • uc004bbk.3,
  • ALDO2,
  • X01098
  • identifiers:
  • 229,
  • ENSG00000136872,
  • ALDOB

Genome feature

Region: gene ? Length: 15221  
Location: 9:101420560-101435780 reverse strand Cyto location: 9q31.1


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Disease

1 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

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Homology

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Expression

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Other

455 SN Ps

5 Cross References

19 Data Sets

9 Homologues

0 Located Features

90 Rna Seq Results