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Gene : PAM Homo sapiens

Name  ? peptidylglycine alpha-amidating monooxygenase Cytological Location  5q21.1
Brief Description  peptidylglycine alpha-amidating monooxygenase
description  This gene encodes a multifunctional protein. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme includes two domains with distinct catalytic activities, a peptidylglycine alpha-hydroxylating monooxygenase (PHM) domain and a peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) domain. These catalytic domains work sequentially to catalyze the conversion of neuroendocrine peptides to active alpha-amidated products. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
  • synonyms:
  • peptidylglycine alpha-hydroxylating monooxygenase,
  • OTTHUMG00000128729,
  • HGNC:8596,
  • PAL,
  • uc003knt.4,
  • NM_000919,
  • PHM,
  • peptidyl-alpha-hydroxyglycine alpha-amidating lyase,
  • PAL,
  • AB095007,
  • PAM,
  • PHM
  • identifiers:
  • 5066,
  • ENSG00000145730,
  • PAM

Genome feature

Region: gene ? Length: 276323  
Location: 5:102754783-103031105 Cyto location: 5q21.1


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0 Pathways

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Genomics

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Proteins

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SNPs

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Disease

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Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Homology

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Expression

Gene(s) --> Significant SNPs (GTex data)

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Other

0 Pathways

2011 SN Ps

5 Cross References

16 Data Sets

9 Homologues

0 Located Features

90 Rna Seq Results