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Gene : MS4A2 Homo sapiens

Name  ? membrane spanning 4-domains A2 Cytological Location  11q12.1
Brief Description  membrane spanning 4-domains A2
description  The allergic response involves the binding of allergen to receptor-bound IgE followed by cell activation and the release of mediators responsible for the manifestations of allergy. The IgE-receptor, a tetramer composed of an alpha, beta, and 2 disulfide-linked gamma chains, is found on the surface of mast cells and basophils. This gene encodes the beta subunit of the high affinity IgE receptor which is a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This family member is localized to 11q12, among a cluster of membrane-spanning 4A gene family members. Alternative splicing results in multiple transcript variants encoding distinct proteins. Additional transcript variants have been described but require experimental validation. [provided by RefSeq, Mar 2012]
  • synonyms:
  • ATOPY,
  • APY,
  • FCER1B,
  • APY,
  • uc001nop.4,
  • MS4A1,
  • IGHER,
  • Fc fragment of IgE, high affinity I, receptor for; beta polypeptide,
  • FCERI,
  • M89796,
  • IGER,
  • IGEL,
  • HGNC:7316,
  • MS4A1,
  • membrane-spanning 4-domains, subfamily A, member 2,
  • OTTHUMG00000167239,
  • IGER,
  • MS4A2,
  • IgE responsiveness (atopic),
  • membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide),
  • FCER1B,
  • NM_000139
  • identifiers:
  • 2206,
  • ENSG00000149534,
  • MS4A2

Genome feature

Region: gene ? Length: 10207  
Location: 11:60088261-60098467 Cyto location: 11q12.1


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Disease

1 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

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Gene -> HPO annotation (Human Phenotype Ontology)

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Expression

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213 SN Ps

5 Cross References

18 Data Sets

45 Homologues

0 Located Features

90 Rna Seq Results