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Gene : RNF111 Homo sapiens

Name  ? ring finger protein 111 Cytological Location  15q22.1-q22.2
Brief Description  ring finger protein 111
description  The protein encoded by this gene is a nuclear RING-domain containing E3 ubiquitin ligase. This protein interacts with the transforming growth factor (TGF) -beta/NODAL signaling pathway by promoting the ubiquitination and proteosomal degradation of negative regulators, like SMAD proteins, and thereby enhances TGF-beta target-gene transcription. As a modulator of the nodal signaling cascade, this gene plays a critical role in the induction of mesoderm during embryonic development. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012]
  • synonyms:
  • OTTHUMG00000132716,
  • ARK,
  • NM_017610,
  • HGNC:17384,
  • FLJ38008,
  • hRNF111,
  • Arkadia,
  • AL157474,
  • ARK,
  • uc002afs.5,
  • RNF111,
  • DKFZP761D081
  • identifiers:
  • 54778,
  • ENSG00000157450,
  • RNF111

Genome feature

Region: gene ? Length: 109832  
Location: 15:58987588-59097419 Cyto location: 15q22.1-q22.2


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Function

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Gene -> HPO annotation (Human Phenotype Ontology)

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Genomics

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Proteins

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SNPs

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Disease

0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Homology

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Interactions

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Expression

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Gene Ontology

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Other

22 SN Ps

5 Cross References

16 Data Sets

5 Homologues

0 Located Features

90 Rna Seq Results