help  | about  | cite  | software

Gene : PRDM9 Homo sapiens

Name  ? PR/SET domain 9 Cytological Location  5p14.2
Brief Description  PR/SET domain 9
description  The protein encoded by this gene is a zinc finger protein with histone methyltransferase activity that catalyzes histone H3 lysine 4 trimethylation (H3K4me3) during meiotic prophase. This protein contains multiple domains, including a Kruppel-associated box (KRAB) domain, an SSX repression domain (SSXRD), a PRD1-BF1 and RIZ homologous region, a subclass of SET (PR/SET) domain, and a tandem array of C2H2 zinc fingers. The zinc finger array recognizes a short sequence motif, leading to local H3K4me3, and meiotic recombination hotspot activity. The observed allelic variation alters the DNA-binding sequence specificity of the protein, resulting in distinct meiotic recombination hotspots amongst individuals and populations. Multiple alternate alleles of this gene have been described. [provided by RefSeq, Jul 2015]
  • synonyms:
  • OTTHUMG00000161918,
  • PRDM9,
  • MSBP3,
  • MEISETZ,
  • AF275816,
  • NM_020227,
  • PR-domain containing protein 9,
  • minisatellite binding protein 3 (115kD),
  • PR domain 9,
  • PFM6,
  • KMT8B,
  • PFM6,
  • PR domain containing 9,
  • ZNF899,
  • HGNC:13994,
  • ZNF899,
  • MSBP3,
  • uc003jgo.3,
  • KMT8B,
  • minisatellite binding protein 3, 115kDa
  • identifiers:
  • 56979,
  • ENSG00000164256,
  • PRDM9

Genome feature

Region: gene ? Length: 20989  
Location: 5:23507609-23528597 Cyto location: 5p14.2


Uni Prot Comments Displayer

Protein Atlas Displayer

Gene Expression Atlas Tissues Displayer

Gene Expression Atlas Diseases Displayer

Publication Counts Displayer

Curated Proteins Displayer

Function

Gene Ontology Displayer

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Genomics

J Browse Displayer

Gene Structure Displayer

Overlapping Features Displayer

Mouse Alleles Displayer

Gene --> Chromosomal location.

Gene --> GO terms.

Gene --> Overlapping genes.

Proteins

Gene --> Proteins.

SNPs

Gene Report --> GWAS hit

Disease

0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Homology

Homologue Displayer

Gene --> Orthologues

Interactions

Cytoscape Network Displayer

Gene --> Physical and Genetic Interactions

Expression

Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.

 

Other

0 SN Ps

5 Cross References

14 Data Sets

17 Homologues

0 Located Features

90 Rna Seq Results