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Gene : GPT Homo sapiens

Name  ? glutamic--pyruvic transaminase Cytological Location  8q24.3
Brief Description  glutamic--pyruvic transaminase
description  This gene encodes cytosolic alanine aminotransaminase 1 (ALT1); also known as glutamate-pyruvate transaminase 1. This enzyme catalyzes the reversible transamination between alanine and 2-oxoglutarate to generate pyruvate and glutamate and, therefore, plays a key role in the intermediary metabolism of glucose and amino acids. Serum activity levels of this enzyme are routinely used as a biomarker of liver injury caused by drug toxicity, infection, alcohol, and steatosis. A related gene on chromosome 16 encodes a putative mitochondrial alanine aminotransaminase.[provided by RefSeq, Nov 2009]
  • synonyms:
  • NM_005309,
  • OTTHUMG00000165176,
  • GPT1,
  • uc033cct.2,
  • GPT,
  • GPT1,
  • HGNC:4552,
  • glutamic-pyruvate transaminase (alanine aminotransferase),
  • alanine transaminase,
  • AAT1,
  • ALT1,
  • ALT1,
  • alanine aminotransferase
  • identifiers:
  • 2875,
  • ENSG00000167701,
  • GPT

Genome feature

Region: gene ? Length: 4958  
Location: 8:144502217-144507174 Cyto location: 8q24.3


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Function

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Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Genomics

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Proteins

Gene --> Proteins.

SNPs

Gene Report --> GWAS hit

Disease

0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Homology

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Interactions

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Expression

Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

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Other

103 SN Ps

5 Cross References

17 Data Sets

9 Homologues

0 Located Features

90 Rna Seq Results