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Gene : KISS1 Homo sapiens

Name  ? KiSS-1 metastasis suppressor Cytological Location  1q32.1
Brief Description  KiSS-1 metastasis suppressor
description  This gene is a metastasis suppressor gene that suppresses metastases of melanomas and breast carcinomas without affecting tumorigenicity. The encoded protein may inhibit chemotaxis and invasion and thereby attenuate metastasis in malignant melanomas. Studies suggest a putative role in the regulation of events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. A protein product of this gene, kisspeptin, stimulates gonadotropin-releasing hormone (GnRH)-induced gonadotropin secretion and regulates the pubertal activation of GnRH nuerons. A polymorphism in the terminal exon of this mRNA results in two protein isoforms. An adenosine present at the polymorphic site represents the third position in a stop codon. When the adenosine is absent, a downstream stop codon is utilized and the encoded protein extends for an additional seven amino acid residues. [provided by RefSeq, Mar 2012]
  • synonyms:
  • NM_002256,
  • HH13,
  • prepro-kisspeptin,
  • uc001har.4,
  • OTTHUMG00000036060,
  • kisspeptin,
  • KiSS-1,
  • HGNC:6341,
  • KISS1,
  • U43527
  • identifiers:
  • 3814,
  • ENSG00000170498,
  • KISS1

Genome feature

Region: gene ? Length: 6151  
Location: 1:204190341-204196491 reverse strand Cyto location: 1q32.1


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Gene -> HPO annotation (Human Phenotype Ontology)

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Genomics

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Proteins

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SNPs

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Disease

1 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Homology

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Interactions

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Expression

Gene(s) --> Significant SNPs (GTex data)

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Other

27 SN Ps

5 Cross References

17 Data Sets

3 Homologues

0 Located Features

90 Rna Seq Results