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Gene : HSD11B2 Homo sapiens

Name  ? hydroxysteroid 11-beta dehydrogenase 2 Cytological Location  16q22.1
Brief Description  hydroxysteroid 11-beta dehydrogenase 2
description  There are at least two isozymes of the corticosteroid 11-beta-dehydrogenase, a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone. The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities. The type II isozyme, encoded by this gene, has only 11-beta-dehydrogenase activity. In aldosterone-selective epithelial tissues such as the kidney, the type II isozyme catalyzes the glucocorticoid cortisol to the inactive metabolite cortisone, thus preventing illicit activation of the mineralocorticoid receptor. In tissues that do not express the mineralocorticoid receptor, such as the placenta and testis, it protects cells from the growth-inhibiting and/or pro-apoptotic effects of cortisol, particularly during embryonic development. Mutations in this gene cause the syndrome of apparent mineralocorticoid excess and hypertension. [provided by RefSeq, Feb 2010]
  • synonyms:
  • HSD11K,
  • NM_000196,
  • hydroxysteroid (11-beta) dehydrogenase 2,
  • SDR9C3,
  • SDR9C3,
  • OTTHUMG00000137507,
  • AME,
  • AME1,
  • short chain dehydrogenase/reductase family 9C, member 3,
  • uc002etd.4,
  • U14631,
  • HGNC:5209,
  • HSD2,
  • HSD11B2
  • identifiers:
  • 3291,
  • ENSG00000176387,
  • HSD11B2

Genome feature

Region: gene ? Length: 6421  
Location: 16:67431133-67437553 Cyto location: 16q22.1


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1 Diseases

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719 SN Ps

5 Cross References

18 Data Sets

11 Homologues

0 Located Features

90 Rna Seq Results