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Gene : HLA-DQA1 Homo sapiens

Name  ? major histocompatibility complex, class II, DQ alpha 1 Cytological Location  6p21.32
Brief Description  major histocompatibility complex, class II, DQ alpha 1
description  HLA-DQA1 belongs to the HLA class II alpha chain paralogues. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa. It is encoded by 5 exons; exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. [provided by RefSeq, Jul 2008]
  • synonyms:
  • DQA1,
  • CELIAC1,
  • CELIAC1,
  • HLA-DQA,
  • DQ-A1,
  • HLA-DQA,
  • OTTHUMG00000031106,
  • HLA-DQA1,
  • HGNC:4942,
  • uc003obr.4,
  • NM_002122
  • identifiers:
  • 3117,
  • ENSG00000196735,
  • HLA-DQA1

Genome feature

Region: gene ? Length: 17441  
Location: 6:32637406-32654846 Cyto location: 6p21.32


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SNPs

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Disease

1 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

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Gene -> HPO annotation (Human Phenotype Ontology)

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Expression

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Other

56687 SN Ps

5 Cross References

17 Data Sets

25 Homologues

0 Located Features

90 Rna Seq Results