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Gene : INS Homo sapiens

Name  ? insulin Cytological Location  11p15.5
Brief Description  insulin
description  This gene encodes insulin, a peptide hormone that plays a vital role in the regulation of carbohydrate and lipid metabolism. After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2019]
  • synonyms:
  • IDDM1,
  • MODY10,
  • ILPR,
  • INS,
  • IDDM2,
  • IDDM,
  • X70508,
  • OTTHUMG00000009558,
  • HGNC:6081,
  • IDDM1,
  • insulin-dependent diabetes mellitus 2,
  • IRDN,
  • IDDM2,
  • NM_000207,
  • uc001lvo.2
  • identifiers:
  • 3630,
  • ENSG00000254647,
  • INS

Genome feature

Region: gene ? Length: 1431  
Location: 11:2159779-2161209 reverse strand Cyto location: 11p15.5


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Function

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Gene --> GO terms.

Mouse Gene --> Allele [Phenotype]

Genomics

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Gene --> GO terms.

Gene --> Overlapping genes.

Proteins

Gene --> Proteins.

SNPs

Gene Report --> GWAS hit

Disease

4 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Mouse Gene --> Allele [Phenotype]

Homology

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Interactions

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Expression

Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.

 

Other

0 SN Ps

5 Cross References

16 Data Sets

7 Homologues

0 Located Features

90 Rna Seq Results