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Gene : ABI1 Homo sapiens

Name  ? abl interactor 1 Cytological Location  10p12.1
Brief Description  abl interactor 1
description  This gene encodes a member of the Abelson-interactor family of adaptor proteins. These proteins facilitate signal transduction as components of several multiprotein complexes, and regulate actin polymerization and cytoskeletal remodeling through interactions with Abelson tyrosine kinases. The encoded protein plays a role in macropinocytosis as a component of the WAVE2 complex, and also forms a complex with EPS8 and SOS1 that mediates signal transduction from Ras to Rac. This gene may play a role in the progression of several malignancies including melanoma, colon cancer and breast cancer, and a t(10;11) chromosomal translocation involving this gene and the MLL gene has been associated with acute myeloid leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 14. [provided by RefSeq, Sep 2011]
  • synonyms:
  • E3B1,
  • HGNC:11320,
  • abl-interactor 1,
  • NAP1BP,
  • SSH3BP,
  • ABI1,
  • uc001isx.4,
  • ABI-1,
  • spectrin SH3 domain binding protein 1,
  • SSH3BP1,
  • E3B1,
  • SSH3BP1,
  • ABLBP4,
  • ABI-1,
  • NM_005470,
  • U87166,
  • OTTHUMG00000017848
  • identifiers:
  • 10006,
  • ENSG00000136754,
  • ABI1

Genome feature

Region: gene ? Length: 114492  
Location: 10:26746596-26861087 reverse strand Cyto location: 10p12.1


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119 SN Ps

5 Cross References

15 Data Sets

9 Homologues

0 Located Features

90 Rna Seq Results