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Gene : IL18BP Homo sapiens

Name  ? interleukin 18 binding protein Cytological Location  11q13.4
Brief Description  interleukin 18 binding protein
description  The protein encoded by this gene functions as an inhibitor of the proinflammatory cytokine, IL18. It binds IL18, prevents the binding of IL18 to its receptor, and thus inhibits IL18-induced IFN-gamma production, resulting in reduced T-helper type 1 immune responses. This protein is constitutively expressed and secreted in mononuclear cells. Elevated level of this protein is detected in the intestinal tissues of patients with Crohn's disease. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]
  • synonyms:
  • IL18BP,
  • IL18BPa,
  • HGNC:5987,
  • IL18BPa,
  • AF110798,
  • OTTHUMG00000133713,
  • NM_173042,
  • uc001orf.2,
  • MC51L-53L-54L homolog gene product
  • identifiers:
  • 10068,
  • ENSG00000137496,
  • IL18BP

Genome feature

Region: gene ? Length: 4976  
Location: 11:71997944-72002919 Cyto location: 11q13.4


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Disease

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171 SN Ps

5 Cross References

15 Data Sets

2 Homologues

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90 Rna Seq Results