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Gene : MRVI1 Homo sapiens

Name  ? murine retrovirus integration site 1 homolog Cytological Location  11p15.4
Brief Description  murine retrovirus integration site 1 homolog
description  This gene is similar to a putative mouse tumor suppressor gene (Mrvi1) that is frequently disrupted by mouse AIDS-related virus (MRV). The encoded protein, which is found in the membrane of the endoplasmic reticulum, is similar to Jaw1, a lymphoid-restricted protein whose expression is down-regulated during lymphoid differentiation. This protein is a substrate of cGMP-dependent kinase-1 (PKG1) that can function as a regulator of IP3-induced calcium release. Studies in mouse suggest that MRV integration at Mrvi1 induces myeloid leukemia by altering the expression of a gene important for myeloid cell growth and/or differentiation, and thus this gene may function as a myeloid leukemia tumor suppressor gene. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene, and alternative translation start sites, including a non-AUG (CUG) start site, are used. [provided by RefSeq, May 2011]
  • synonyms:
  • IP3R-associated cGMP kinase substrate,
  • OTTHUMG00000165773,
  • IRAG,
  • NM_001098579,
  • JAW1L,
  • uc010rcc.2,
  • HGNC:7237,
  • inositol 1,4,5-triphosphate-associated cGMP kinase substrate,
  • IRAG,
  • MRVI1,
  • AF081249,
  • JAW1L
  • identifiers:
  • 10335,
  • ENSG00000072952,
  • MRVI1

Genome feature

Region: gene ? Length: 120898  
Location: 11:10573091-10693988 reverse strand Cyto location: 11p15.4

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0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

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Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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200 SN Ps

5 Cross References

16 Data Sets

4 Homologues

0 Located Features

90 Rna Seq Results