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Gene : NOD1 Homo sapiens

Name  ? nucleotide binding oligomerization domain containing 1 Cytological Location  7p14.3
Brief Description  nucleotide binding oligomerization domain containing 1
description  This gene encodes a member of the nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) family of proteins. The encoded protein plays a role in innate immunity by acting as a pattern-recognition receptor (PRR) that binds bacterial peptidoglycans and initiates inflammation. This protein has also been implicated in the immune response to viral and parasitic infection. Major structural features of this protein include an N-terminal caspase recruitment domain (CARD), a centrally located nucleotide-binding domain (NBD), and 10 tandem leucine-rich repeats (LRRs) in its C terminus. The CARD is involved in apoptotic signaling, LRRs participate in protein-protein interactions, and mutations in the NBD may affect the process of oligomerization and subsequent function of the LRR domain. Mutations in this gene are associated with asthma, inflammatory bowel disease, Behcet disease and sarcoidosis in human patients. [provided by RefSeq, Aug 2017]
  • synonyms:
  • CLR7.1,
  • AF126484,
  • NLRC1,
  • NLR family, CARD domain containing 1,
  • nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 1,
  • OTTHUMG00000023923,
  • CARD4,
  • CARD4,
  • NM_001354849,
  • caspase recruitment domain family, member 4,
  • CLR7.1,
  • NOD1,
  • uc003tav.4,
  • NLRC1,
  • HGNC:16390
  • identifiers:
  • 10392,
  • ENSG00000106100,
  • NOD1

Genome feature

Region: gene ? Length: 54340  
Location: 7:30424527-30478866 reverse strand Cyto location: 7p14.3

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0 Diseases

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454 SN Ps

5 Cross References

17 Data Sets

7 Homologues

0 Located Features

90 Rna Seq Results