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Gene : DRAP1 Homo sapiens

Name  ? DR1 associated protein 1 Cytological Location  11q13.1
Brief Description  DR1 associated protein 1
description  Transcriptional repression is a general mechanism for regulating transcriptional initiation in organisms ranging from yeast to humans. Accurate initiation of transcription from eukaryotic protein-encoding genes requires the assembly of a large multiprotein complex consisting of RNA polymerase II and general transcription factors such as TFIIA, TFIIB, and TFIID. DR1 is a repressor that interacts with the TATA-binding protein (TBP) of TFIID and prevents the formation of an active transcription complex by precluding the entry of TFIIA and/or TFIIB into the preinitiation complex. The protein encoded by this gene is a corepressor of transcription that interacts with DR1 to enhance DR1-mediated repression. The interaction between this corepressor and DR1 is required for corepressor function and appears to stabilize the TBP-DR1-DNA complex. [provided by RefSeq, Jul 2008]
  • synonyms:
  • HGNC:3019,
  • uc001ogj.3,
  • NC2-alpha,
  • negative cofactor 2 alpha,
  • OTTHUMG00000166723,
  • DR1-associated corepressor,
  • U41843,
  • NC2-alpha,
  • DRAP1,
  • NM_006442
  • identifiers:
  • 10589,
  • ENSG00000175550,
  • DRAP1

Genome feature

Region: gene ? Length: 2321  
Location: 11:65919257-65921577 Cyto location: 11q13.1


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37 SN Ps

5 Cross References

15 Data Sets

9 Homologues

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90 Rna Seq Results