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Gene : LOC107648859 Homo sapiens

Name  ? meiotic recombination hotspot DMB2 Cytological Location  6p21.3
description  This region is upstream of the major histocompatibility complex, class II, DM beta (HLA-DMB) gene on the p arm of chromosome 6 relative to the reference genome. This region has been identified as a meiotic recombination hotspot by sperm typing assays, molecular assays in male germ cells to identify meiotic double strand breaks, and linkage disequilibrium studies. HapMap data shows an increased recombination rate in the region. Another meiotic recombination hotspot has been identified close to this region and is located within the HLA-DMB gene. Higher recombination frequencies in females relative to males has been reported in the MHC class II region. Meiotic hotspot activity can vary widely amongst individuals and can be influenced by both the nucleotide sequence at the meiotic recombination hotspot and the specific alleles present at the PR domain 9 (PRDM9) locus. A linkage disequilibrium 'CCNCCNTNNCCNC' motif is found in this region. [provided by RefSeq, Oct 2016]
  • identifiers:
  • 107648859,
  • LOC107648859

Genome feature

Region: gene ?
Location: No location information in HumanMine Cyto location: 6p21.3


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