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Gene : KDELR3 Homo sapiens

Name  ? KDEL endoplasmic reticulum protein retention receptor 3 Cytological Location  22q13.1
Brief Description  KDEL endoplasmic reticulum protein retention receptor 3
description  This gene encodes a member of the KDEL endoplasmic reticulum protein retention receptor family. Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. KDELR3 was the third member of the family to be identified. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
  • synonyms:
  • OTTHUMG00000153520,
  • HGNC:6306,
  • NM_006855,
  • uc003avv.4,
  • KDELR3,
  • AL035081,
  • KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3,
  • ERD2L3
  • identifiers:
  • 11015,
  • ENSG00000100196,
  • KDELR3

Genome feature

Region: gene ? Length: 15386  
Location: 22:38468062-38483447 Cyto location: 22q13.1


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389 SN Ps

4 Cross References

16 Data Sets

8 Homologues

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90 Rna Seq Results