help  | about  | cite  | software

Gene : ADAMTS8 Homo sapiens

Name  ? ADAM metallopeptidase with thrombospondin type 1 motif 8 Cytological Location  11q24.3
Brief Description  ADAM metallopeptidase with thrombospondin type 1 motif 8
description  This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme contains two C-terminal TS motifs, and disrupts angiogenesis in vivo. A number of disorders have been mapped in the vicinity of this gene, most notably lung neoplasms. Reduced expression of this gene has been observed in multiple human cancers and this gene has been proposed as a potential tumor suppressor. [provided by RefSeq, Feb 2016]
  • synonyms:
  • uc001qgg.5,
  • METH2,
  • ADAM-TS8,
  • METH2,
  • AF060153,
  • FLJ41712,
  • OTTHUMG00000165656,
  • ADAM-TS8,
  • HGNC:224,
  • ADAMTS8,
  • a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 8,
  • NM_007037
  • identifiers:
  • 11095,
  • ENSG00000134917,
  • ADAMTS8

Genome feature

Region: gene ? Length: 24071  
Location: 11:130404923-130428993 reverse strand Cyto location: 11q24.3


Uni Prot Comments Displayer

Protein Atlas Displayer

Gene Expression Atlas Tissues Displayer

Gene Expression Atlas Diseases Displayer

Publication Counts Displayer

Curated Proteins Displayer

Function

Gene Ontology Displayer

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Genomics

J Browse Displayer

Gene Structure Displayer

Overlapping Features Displayer

Mouse Alleles Displayer

Gene --> Chromosomal location.

Gene --> GO terms.

Gene --> Overlapping genes.

Proteins

Gene --> Proteins.

SNPs

Gene Report --> GWAS hit

Disease

0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Homology

Homologue Displayer

Gene --> Orthologues

Interactions

Cytoscape Network Displayer

Gene --> Physical and Genetic Interactions

Expression

Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.

 

Other

64 SN Ps

4 Cross References

15 Data Sets

34 Homologues

0 Located Features

90 Rna Seq Results